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By extrapolation from the established profiles of approved GLP-1 receptor agonists including semaglutide (Wegovy SmPC, MHRA/EMC) and tirzepatide (Mounjaro SmPC, MHRA/EMC) clinicians should anticipate the need to review and potentially reduce antihypertensive doses as significant weight loss occurs, in line with BNF and NICE guidance principles

Tryptophan in the diet ameliorates motor deficits in a rotenone-induced rat Parkinsons disease model via activating the aromatic hydrocarbon receptor pathway

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Flaherty S, Strauch P, Maktabi M, Pybus BS, Reichard G, Walker LA, et al